The aim of this paper is to develop a computerized simulation of a hybrid vehicle in AVL Cruise software, (based on constructive parameters of Toyota Prius-3rd Generation) to run it on eight different Driving Cycles, and to compare its results. These results will be analyzed from a vehicle performance as well as from a fuel and energy consumption points of view. The cycles used in this paper are: NEDC (New European Driving Cycle), WLTC (Worldwide harmonized Light vehicles Test Cycle), JC08 (Japanese Cycle), FTP-75 (Federal Test Procedure), Australian CUEDC (Composite Urban Emissions Drive Cycle), Artemis Driving Cycle, Chinese C-WTVC (World Transient Vehicle Cycle) and Modem Hyzem. Based on these results, it will be established which driving cycle is the most representative for the actual mobility needs. To create the comparison of these eight driving cycles, it is necessary to evaluate the obtained results on each cycle, and for 100 km and for the entire life span of the vehicle (200.000 km, according to 2009/33/CE). The energetic efficiency (fuel and energy consumption) along with pollutant emissions (main emissions calculated based on existing regulations of the considered engine) will be considered.