The paper aims to identify solutions for traffic safety enhancement in an urban area where major changes in traffic flow intensity and pattern will occur. The changes of the study area pattern will be caused, on the one hand, by the development of new residential and office areas and, on the other hand, by the opening of a new road overpass linking the inner urban area with an outside area where peri- and regional traffic flow are concentrated. The assessment of the traffic systematization solutions under these new conditions is based on a simulation model developed with the AIMSUN software. The study area is located in Bucharest, around the zone of University Politehnica of Bucharest Campus. The main difficulty of the model consists in the prediction of the exogenous traffic data of the study area. The simulation model is applied for one proposed scenario considering  the increase of the traffic flow intensities. A set of measures for traffic systematization is assessed and compared based on flow features (speed, frequency and time of stops, external effects limitations).